As the flowers are finally starting to bloom in my garden, we will take a look at an intriguing study which uses ultrasound to reverse cellular senescence and increase mouse lifespan; two studies on reducing lower back pain, the first using epigenetic reprogramming, while the second is a Canadian study using senolytics; and, a fascinating study where an induced torpor like state (akin to hibernation) improves healthspan. In the Supplemental Section, you’ll find in Lifestyle a couple of […]

As we emerge from the depth of winter, this month we will take a look at how the combination of Omega 3, Vitamin D and resistance exercise can slow down the aging process; how young blood plasma can help with surgical outcomes in a human trial; how Klotho gene therapy can increase the lifespan of mice; and in the Canadian content study, how cellular reprogramming can protect retinal neurons and maintain vision in a mouse model of multiple sclerosis. In the Supplemental Section, you’ll find […]

Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan. In the Supplemental […]

Hello and welcome to the final longevity review of 2024. This month we will take a look at gene therapy to increase telomere length; freeing the immune system to remove senescent cells; using probiotics to help with sarcopenia; and, in the Canadian content study, employing extracellular vesicles to deliver drugs to the brain to combat neuroinflammation. In the Supplemental Section, you’ll find in Lifestyle how exercise and sleep improve memory the next day; in Diet, how moderate wine […]

As we get closer to the holiday season, this review returns to its monthly format after a brief foray into a bi-monthly issue. Now that I have caught up with these reviews, we will take a look at how 16:8 time restricted eating in healthy, normal weight individuals can still reduce weight and fat mass, as well as improve the immune system and make their gut microbiome younger; how ergothioneine could improve cognition in older individuals with mild cognitive impairment; and for the first time, […]